Yokonolide A, a New Inhibitor of Auxin Signal Transduction, from Streptomyces diastatochromogenes B59.
نویسندگان
چکیده
منابع مشابه
Yokonolide A, a new inhibitor of auxin signal transduction, from Streptomyces diastatochromogenes B59.
Bio-probes that inhibit the action of auxin are useful tools for the study of auxin signaling. To screen for specific inhibitors of auxin signaling, we used an Arabidopsis transgenic line harboring the auxin-inducible promoter derived from PS-IAA4/5 and the reporter gene, GUS (beta-glucuronidase). In this transgenic plant, the exogenous auxin specifically enhanced the expression of the GUS repo...
متن کاملYokonolide B, a novel inhibitor of auxin action, blocks degradation of AUX/IAA factors.
Yokonolide B (YkB; also known as A82548A), a spiroketal-macrolide, was isolated from Streptomyces diastatochromogenes B59 in a screen for inhibitors of beta-glucoronidase expression under the control of an auxin-responsive promoter in Arabidopsis. YkB inhibits the expression of auxin-inducible genes as shown using native and synthetic auxin promoters as well as using expression profiling of 830...
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Auxin regulates a broad spectrum of developmental processes, mediating transcriptional regulation via protein degradation. The molecular mechanisms of auxin action are partially understood whereas the molecular basis for developmental specificity in auxin responses is currently unclear. Recent biochemical and chemical-genetics studies have narrowed the search for regulators in auxin signaling t...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2001
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.54.573